Your browser doesn't support javascript.
loading
Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma.
Abousaida, Belal; Seneviratne, Danushka; Hoppe, Bradford S; Ko, Stephen J; Asaithamby, Aroumougame; Cucinotta, Francis A; Kirwan, Jessica M; Mody, Kabir; Toskich, Beau; Ashman, Jonathan B; Hallemeier, Christopher L; Krishnan, Sunil.
Afiliação
  • Abousaida B; Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Seneviratne D; Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Hoppe BS; Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Ko SJ; Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Asaithamby A; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Cucinotta FA; School of Integrated Health Sciences, University of Las Vegas, Las Vegas, NV, USA.
  • Kirwan JM; Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
  • Mody K; Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Toskich B; Division of Interventional Radiology, Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Ashman JB; Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
  • Hallemeier CL; Department of Radiation Oncology, Mayo Clinic Rochester, Rochester, MN, USA.
  • Krishnan S; Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
J Hepatocell Carcinoma ; 8: 1169-1179, 2021.
Article em En | MEDLINE | ID: mdl-34595139
Localized hepatocellular carcinoma (HCC) that is unresectable and non-transplantable can be treated by several liver-directed therapies. External beam radiation therapy (EBRT) is an increasingly accepted and widely utilized treatment modality in this setting. Accelerated charged particles such as proton beam therapy (PBT) and carbon ion radiation therapy (CIRT) offer technological advancements over conventional photon radiotherapy. In this review, we summarize the distinct advantages of CIRT use for HCC treatment, focusing on physical and biological attributes, and outline dosimetric and treatment planning caveats. Based on these considerations, we posit that HCC may be among the best indications for use of CIRT, as it allows for maximizing tumoricidal doses to the target volume while minimizing the dose to the organs at risk.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Hepatocell Carcinoma Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Hepatocell Carcinoma Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos