Primary and secondary focal choroidal excavation morphologic phenotypes, associated ocular disorders and prognostic implications.
Br J Ophthalmol
; 107(3): 373-379, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-34656984
ABSTRACT
AIMS:
To characterise and classify the morphological, clinical and tomographic characteristics of focal choroidal excavation (FCE) lesions to determine their prognostic implications.METHODS:
36 eyes with FCE (32 patients) underwent multimodal imaging, including spectral domain optical coherence tomography and fundus autofluorescence. FCE lesions were classified into three subtypes (1) type 1 myopic (central choroidal thickness <100 µm), (2) type 2 suspected congenital (central choroidal thickness 100-200 µm, without associated chorioretinal pathology) and (3) type 3 secondary or acquired (central choroidal thickness >200 µm, with associated chorioretinal pathology).RESULTS:
80.6% of eyes were followed longitudinally (26.8±18.8 months). There were 9 type 1 FCEs (myopic), 8 type 2 FCEs (U-shaped, congenital) and 19 type 3 FCEs (V-shaped, secondary). Type 2 FCEs trended towards larger maximum widths (p=0.0563). Type 3 FCEs were associated with central serous chorioretinopathy or pachyvessels (47.4%), but were also seen in pattern dystrophy, geographic atrophy, inactive choroiditis, torpedo maculopathy and adult-onset vitelliform dystrophy. Choroidal neovascular membranes (CNVMs) were more prevalent in type 3 FCE (41.2% compared with 11.1% for type 1 FCE, p=0.251, and 0% for type 2 FCE, p=0.043).CONCLUSIONS:
The FCE types, stratified by central choroidal thickness, demonstrated distinct morphological characteristics and associated findings. The classification scheme held prognostic implications as type 3 FCE with V shapes were associated with other chorioretinal conditions and were more likely to develop CNVM.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Coroide
/
Coriorretinopatia Serosa Central
/
Distrofia Macular Viteliforme
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Br J Ophthalmol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos