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Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer.
Leblanc, Eric; Ban, Fuqiang; Cavga, Ayse Derya; Lawn, Sam; Huang, Chia-Chi Flora; Mohan, Sankar; Chang, Matthew E K; Flory, Mark R; Ghaidi, Fariba; Lingadahalli, Shreyas; Chen, Gang; Yu, Ivan Pak Lok; Morin, Hélène; Lallous, Nada; Gleave, Martin E; Mohammed, Hisham; Young, Robert N; Rennie, Paul S; Lack, Nathan A; Cherkasov, Artem.
Afiliação
  • Leblanc E; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Ban F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Cavga AD; School of Medicine, Koç University, Rumelifeneri Yolu, Istanbul 34450, Turkey.
  • Lawn S; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Huang CF; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Mohan S; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada.
  • Chang MEK; Knight Cancer Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239, United States.
  • Flory MR; Knight Cancer Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239, United States.
  • Ghaidi F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Lingadahalli S; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Chen G; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada.
  • Yu IPL; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Morin H; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Lallous N; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Gleave ME; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Mohammed H; Knight Cancer Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239, United States.
  • Young RN; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada.
  • Rennie PS; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Lack NA; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.
  • Cherkasov A; School of Medicine, Koç University, Rumelifeneri Yolu, Istanbul 34450, Turkey.
J Med Chem ; 64(20): 14968-14982, 2021 10 28.
Article em En | MEDLINE | ID: mdl-34661404
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Receptores Androgênicos / Neoplasias de Próstata Resistentes à Castração / Desenvolvimento de Medicamentos / Antagonistas de Androgênios / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Receptores Androgênicos / Neoplasias de Próstata Resistentes à Castração / Desenvolvimento de Medicamentos / Antagonistas de Androgênios / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá