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Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.
Omenn, Gilbert S; Lane, Lydie; Overall, Christopher M; Paik, Young-Ki; Cristea, Ileana M; Corrales, Fernando J; Lindskog, Cecilia; Weintraub, Susan; Roehrl, Michael H A; Liu, Siqi; Bandeira, Nuno; Srivastava, Sudhir; Chen, Yu-Ju; Aebersold, Ruedi; Moritz, Robert L; Deutsch, Eric W.
Afiliação
  • Omenn GS; University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Lane L; Institute for Systems Biology, Seattle, Washington 98109, United States.
  • Overall CM; CALIPHO Group, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Paik YK; University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
  • Cristea IM; Yonsei Proteome Research Center and Yonsei University, Seoul 03722, Korea.
  • Corrales FJ; Princeton University, Princeton, New Jersey 08544, United States.
  • Lindskog C; Centro Nacional de Biotecnologia, 28049 Madrid, Spain.
  • Weintraub S; Uppsala University, 752 36 Uppsala, Sweden.
  • Roehrl MHA; University of Texas Health, San Antonio, San Antonio, Texas 78229-3900, United States.
  • Liu S; Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
  • Bandeira N; BGI Group, Shenzhen 518083, China.
  • Srivastava S; University of California, San Diego, La Jolla, California 92093, United States.
  • Chen YJ; National Cancer Institute, Rockville, Maryland 20850, United States.
  • Aebersold R; National Taiwan University, Academia Sinica, Nankang, Taipei 11529, Taiwan.
  • Moritz RL; ETH-Zurich and University of Zurich, 8092 Zurich, Switzerland.
  • Deutsch EW; Institute for Systems Biology, Seattle, Washington 98109, United States.
J Proteome Res ; 20(12): 5227-5240, 2021 12 03.
Article em En | MEDLINE | ID: mdl-34670092
The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, Musculo-Skeletal, Liver, and Cancers B/D-HPP teams and from the Knowledgebase, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benchmarking / Proteoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benchmarking / Proteoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos