Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y<sub>14</sub>R antagonists with anti-gout potential.

Zhou, Mengze; Wang, Weiwei; Wang, Zhongkui; Wang, Yilin; Zhu, Yifan; Lin, Zhiqian; Tian, Sheng; Huang, Yuan; Hu, Qinghua; Li, Huanqiu

Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y₁₄R antagonists with anti-gout potential.

Zhou, Mengze; Wang, Weiwei; Wang, Zhongkui; Wang, Yilin; Zhu, Yifan; Lin, Zhiqian; Tian, Sheng; Huang, Yuan; Hu, Qinghua; Li, Huanqiu.

Afiliação

Zhou M; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Wang W; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Wang Z; Department of Neurology, Hebei Yanda Hospital, NO.6 Sipulan Road, Sanhe, Hebei, 065201, China.
Wang Y; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Zhu Y; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Lin Z; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Tian S; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. Electronic address: stian@suda.edu.cn.
Huang Y; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Hu Q; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: huqh@cpu.edu.cn.
Li H; Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. Electronic address: huanqiuli@suda.edu.cn.

Eur J Med Chem ; 227: 113933, 2022 Jan 05.

Article em En | MEDLINE | ID: mdl-34689072

Assuntos

Acetamidas/farmacologia; Benzoxazóis/farmacologia; Descoberta de Drogas; Gota/tratamento farmacológico; Antagonistas do Receptor Purinérgico P2/farmacologia; Receptores Purinérgicos P2Y/metabolismo; Acetamidas/síntese química; Acetamidas/química; Animais; Benzoxazóis/síntese química; Benzoxazóis/química; Células Cultivadas; Relação Dose-Resposta a Droga; Gota/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos ICR; Simulação de Acoplamento Molecular; Estrutura Molecular; Antagonistas do Receptor Purinérgico P2/síntese química; Antagonistas do Receptor Purinérgico P2/química; Relação Estrutura-Atividade

Palavras-chave

2-Phenyl-benzoxazole acetamide; Acute gouty arthritis; Antagonist; Anti-inflammatory; Binding mechanism; P2Y(14) receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzoxazóis / Descoberta de Drogas / Receptores Purinérgicos P2Y / Antagonistas do Receptor Purinérgico P2 / Gota / Acetamidas Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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