A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU/NSP15): <i>in silico</i> and <i>in vitro</i> investigations.

Kumar, Sumit; Gupta, Yash; Zak, Samantha E; Upadhyay, Charu; Sharma, Neha; Herbert, Andrew S; Durvasula, Ravi; Potemkin, Vladimir; Dye, John M; Kempaiah, Prakasha; Rathi, Brijesh

A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU/NSP15): in silico and in vitro investigations.

Kumar, Sumit; Gupta, Yash; Zak, Samantha E; Upadhyay, Charu; Sharma, Neha; Herbert, Andrew S; Durvasula, Ravi; Potemkin, Vladimir; Dye, John M; Kempaiah, Prakasha; Rathi, Brijesh.

Afiliação

Kumar S; Department of Chemistry, Miranda House, University of Delhi Delhi India poonam.chemistry@mirandahouse.ac.in.
Gupta Y; Division of Infectious Diseases Mayo Clinic, Jacksonville Florida USA Kempaiah.Prakasha@mayo.edu.
Zak SE; United States Army Medical Research Institute of Infectious Diseases Fort Detrick MD USA.
Upadhyay C; The Geneva Foundation 917 Pacific Avenue Tacoma WA USA.
Sharma N; Department of Chemistry, Miranda House, University of Delhi Delhi India poonam.chemistry@mirandahouse.ac.in.
Herbert AS; Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi India brijeshrathi@hrc.du.ac.in.
Durvasula R; United States Army Medical Research Institute of Infectious Diseases Fort Detrick MD USA.
Potemkin V; Division of Infectious Diseases Mayo Clinic, Jacksonville Florida USA Kempaiah.Prakasha@mayo.edu.
Dye JM; South Ural State University, Laboratory of Computational Modelling of Drugs 454080 Russia.
Poonam; United States Army Medical Research Institute of Infectious Diseases Fort Detrick MD USA.
Kempaiah P; The Geneva Foundation 917 Pacific Avenue Tacoma WA USA.
Rathi B; Department of Chemistry, Miranda House, University of Delhi Delhi India poonam.chemistry@mirandahouse.ac.in.

RSC Med Chem ; 12(10): 1757-1764, 2021 Oct 20.

Article em En | MEDLINE | ID: mdl-34778776

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Med Chem Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Med Chem Ano de publicação: 2021 Tipo de documento: Article