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Maternal carbohydrate intake during pregnancy is associated with child peripubertal markers of metabolic health but not adiposity.
Mulcahy, Molly C; Tellez-Rojo, Martha Maria; Cantoral, Alejandra; Solano-González, Maritsa; Baylin, Ana; Bridges, Dave; Peterson, Karen E; Perng, Wei.
Afiliação
  • Mulcahy MC; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Tellez-Rojo MM; Center for Nutrition and Health Research, Instituto de Salud Pública, Cuernavaca, Morelos, Mexico.
  • Cantoral A; Department of Health, Universidad Iberoamericana, Prolongación Paseo de Reforma 880, Lomas de Santa Fe, Ciudad de México, C.P. 01219, Mexico.
  • Solano-González M; Center for Nutrition and Health Research, Instituto de Salud Pública, Cuernavaca, Morelos, Mexico.
  • Baylin A; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Bridges D; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Peterson KE; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Perng W; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Public Health Nutr ; 25(9): 2541-2553, 2022 09.
Article em En | MEDLINE | ID: mdl-34814962
OBJECTIVE: To examine the associations of trimester-specific maternal prenatal carbohydrate (CHO) intake with offspring adiposity and metabolic health during peripuberty. DESIGN: Prospective cohort study in which maternal dietary intake was collected via validated FFQ during each trimester. Offspring adiposity and metabolic biomarkers were evaluated at age 8-14 years. We used multivariable linear regression to examine associations between total energy-adjusted maternal CHO intake and offspring BMI z-score, skinfold thickness and metabolic syndrome risk z-score calculated as the average of waist circumference, fasting glucose, fasting C-peptide, TAG:HDL and systolic blood pressure + diastolic blood pressure/2. SETTING: Mexico City, Mexico. PARTICIPANTS: 237 mother-child pairs in the Early Life Exposure in Mexico to Environmental Toxicants cohort. RESULTS: We found non-linear associations of maternal CHO intake during pregnancy with offspring metabolic health during peripuberty. After adjusting for maternal age, and child age, sex and pubertal status, children whose mothers were in the fourth v. first quartile of total CHO intake during the third trimester had 0·42 (95 % CI -0·01, 0·08) ng/ml lower C-peptide and 0·10 (95 % CI -0·02, 0·22) units lower C-peptide insulin resistance (CP-IR). We found similar magnitude and direction of association with respect to net CHO intake during the first trimester and offspring C-peptide and CP-IR. Maternal CHO intake during pregnancy was not associated with offspring adiposity. CONCLUSIONS: In this study of mother-child pairs in Mexico City, children born to women in the highest quartile of CHO intake during pregnancy had lowest C-peptide and CP-IR during peripuberty. Additional research is warranted to replicate and identify mechanisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Adiposidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans Idioma: En Revista: Public Health Nutr Assunto da revista: CIENCIAS DA NUTRICAO / SAUDE PUBLICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Adiposidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans Idioma: En Revista: Public Health Nutr Assunto da revista: CIENCIAS DA NUTRICAO / SAUDE PUBLICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos