Your browser doesn't support javascript.
loading
Evaluation of sociodemographic and baseline patient characteristic differences in cervical cancer patients treated with either external beam or brachytherapy boost.
Lu, Diana J; Atkins, Katelyn M; Small, William; Kamrava, Mitchell.
Afiliação
  • Lu DJ; Cedars-Sinai Medical Center, Department of Radiation Oncology, Los Angeles, CA. Electronic address: Diana.Lu2@cshs.org.
  • Atkins KM; Cedars-Sinai Medical Center, Department of Radiation Oncology, Los Angeles, CA.
  • Small W; Loyola University Chicago, Stritch School of Medicine, Department of Radiation Oncology, Cardinal Bernardin Cancer Center, Maywood, IL.
  • Kamrava M; Cedars-Sinai Medical Center, Department of Radiation Oncology, Los Angeles, CA.
Brachytherapy ; 21(1): 22-28, 2022.
Article em En | MEDLINE | ID: mdl-34895839
PURPOSE: Chemoradiation is considered the standard of care for locally advanced cervical cancer. While brachytherapy (BT) boost is associated with improved survival and less toxicity compared to external beam radiation therapy (EBRT) boost, it is unclear why many patients do not receive a BT boost. In this study, we compared sociodemographic and baseline patient characteristics between patients receiving EBRT boost versus BT boost. METHODS: We analyzed patients in the National Cancer Database diagnosed between 2004 and 2016 with FIGO stage IIB-IVA cervical cancer treated with nonpalliative doses of chemoradiation. Logistic regression analysis was utilized to evaluate BT utilization over time and by other clinicopathological and sociodemographic factors. RESULTS: Overall, 5764 patients were evaluated, of which 4937 (86%) underwent BT boost. Using multivariable logistic regression, higher FIGO stage was a significant predictor for utilization of EBRT versus BT boost, with odds ratio 2.92 (95% confidence interval [CI] 2.04-4.16; p < 0.001), 2.68 (95%CI 2.22-3.24; p < 0.001), and 4.51 (95%CI 3.05-6.67; p < 0.001) for IIIA, IIIB, and IVA, respectively, compared to IIB. Increased utilization of EBRT boost was also associated with community cancer facility types, lower income (based on zip code), earlier year of diagnosis, and higher comorbidity score. CONCLUSIONS: In FIGO stage IIB-IVA cervical cancer patients treated with nonpalliative doses of chemoradiation, overall utilization of BT is 86%. Higher FIGO stage, community cancer facilities, lower income, earlier year of diagnosis, and higher comorbidity score were significant predictors of EBRT boost utilization. Future studies are needed to better understand reasons for this as higher FIGO stage patients are the mostly likely to benefit from a BT boost.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Braquiterapia / Neoplasias do Colo do Útero Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: Brachytherapy Assunto da revista: RADIOTERAPIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Braquiterapia / Neoplasias do Colo do Útero Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: Brachytherapy Assunto da revista: RADIOTERAPIA Ano de publicação: 2022 Tipo de documento: Article