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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
Wilson, Caroline; Ray, Peter; Zuccotto, Fabio; Hernandez, Jorge; Aggarwal, Anup; Mackenzie, Claire; Caldwell, Nicola; Taylor, Malcolm; Huggett, Margaret; Mathieson, Michael; Murugesan, Dinakaran; Smith, Alasdair; Davis, Susan; Cocco, Mattia; Parai, Maloy K; Acharya, Arjun; Tamaki, Fabio; Scullion, Paul; Epemolu, Ola; Riley, Jennifer; Stojanovski, Laste; Lopez-Román, Eva Maria; Torres-Gómez, Pedro Alfonso; Toledo, Ana Maria; Guijarro-Lopez, Laura; Camino, Isabel; Engelhart, Curtis A; Schnappinger, Dirk; Massoudi, Lisa M; Lenaerts, Anne; Robertson, Gregory T; Walpole, Chris; Matthews, David; Floyd, David; Sacchettini, James C; Read, Kevin D; Encinas, Lourdes; Bates, Robert H; Green, Simon R; Wyatt, Paul G.
Afiliação
  • Wilson C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Ray P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Zuccotto F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Hernandez J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Aggarwal A; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
  • Mackenzie C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Caldwell N; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Taylor M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Huggett M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Mathieson M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Murugesan D; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Smith A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Davis S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Cocco M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Parai MK; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
  • Acharya A; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
  • Tamaki F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Scullion P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Epemolu O; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Stojanovski L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Lopez-Román EM; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Torres-Gómez PA; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Toledo AM; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Guijarro-Lopez L; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Camino I; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Engelhart CA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
  • Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
  • Massoudi LM; Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States.
  • Lenaerts A; Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States.
  • Robertson GT; Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States.
  • Walpole C; Structural Genomics Consortium, Research Institute of the McGill University Health Centre, 1001 Boulevard Décarie, Site Glen Block E, ES1.1614, Montréal, Québec H4A 3J1, Canada.
  • Matthews D; Structural Genomics Consortium, Research Institute of the McGill University Health Centre, 1001 Boulevard Décarie, Site Glen Block E, ES1.1614, Montréal, Québec H4A 3J1, Canada.
  • Floyd D; Structural Genomics Consortium, Research Institute of the McGill University Health Centre, 1001 Boulevard Décarie, Site Glen Block E, ES1.1614, Montréal, Québec H4A 3J1, Canada.
  • Sacchettini JC; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
  • Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Encinas L; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Bates RH; Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Green SR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
J Med Chem ; 65(1): 409-423, 2022 01 13.
Article em En | MEDLINE | ID: mdl-34910486
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitoil-CoA Hidrolase / Piperidinas / Proteínas de Bactérias / Benzofuranos / Policetídeo Sintases / Antituberculosos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitoil-CoA Hidrolase / Piperidinas / Proteínas de Bactérias / Benzofuranos / Policetídeo Sintases / Antituberculosos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article