Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.

Sangaralingham, S Jeson; Whig, Kanupriya; Peddibhotla, Satyamaheshwar; Kirby, R Jason; Sessions, Hampton E; Maloney, Patrick R; Hershberger, Paul M; Mose-Yates, Heather; Hood, Becky L; Vasile, Stefan; Pan, Shuchong; Zheng, Ye; Malany, Siobhan; Burnett, John C

Sangaralingham, S Jeson; Whig, Kanupriya; Peddibhotla, Satyamaheshwar; Kirby, R Jason; Sessions, Hampton E; Maloney, Patrick R; Hershberger, Paul M; Mose-Yates, Heather; Hood, Becky L; Vasile, Stefan; Pan, Shuchong; Zheng, Ye; Malany, Siobhan; Burnett, John C.

Afiliação

Sangaralingham SJ; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905; sangaralingham.jeson@mayo.edu smalany@cop.ufl.edu burnett.john@mayo.edu.
Whig K; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905.
Peddibhotla S; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Kirby RJ; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Sessions HE; Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610.
Maloney PR; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Hershberger PM; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Mose-Yates H; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Hood BL; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Vasile S; Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610.
Pan S; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Zheng Y; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Malany S; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905.
Burnett JC; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905.

Proc Natl Acad Sci U S A ; 118(52)2021 12 28.

Article em En | MEDLINE | ID: mdl-34930837

Assuntos

Fármacos Cardiovasculares; Doenças Cardiovasculares/metabolismo; GMP Cíclico/metabolismo; Peptídeos Natriuréticos/metabolismo; Receptores do Fator Natriurético Atrial; Idoso; Regulação Alostérica; Animais; Fármacos Cardiovasculares/química; Fármacos Cardiovasculares/metabolismo; Fármacos Cardiovasculares/farmacocinética; Fármacos Cardiovasculares/farmacologia; Células Cultivadas; Feminino; Células HEK293; Ensaios de Triagem em Larga Escala; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Miócitos Cardíacos/metabolismo; Receptores do Fator Natriurético Atrial/química; Receptores do Fator Natriurético Atrial/efeitos dos fármacos; Receptores do Fator Natriurético Atrial/metabolismo

Palavras-chave

cardiovascular disease; natriuretic peptides; particulate guanylyl cyclase A receptor; small molecule

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Cardiovasculares / Doenças Cardiovasculares / Receptores do Fator Natriurético Atrial / GMP Cíclico / Peptídeos Natriuréticos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google