<i>N</i>-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy.

Zhou, Jie; Terluk, Marcia R; Orchard, Paul J; Cloyd, James C; Kartha, Reena V

N-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy.

Zhou, Jie; Terluk, Marcia R; Orchard, Paul J; Cloyd, James C; Kartha, Reena V.

Afiliação

Zhou J; Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 2001 6th Street SE, Minneapolis, MN 55455, USA.
Terluk MR; Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 2001 6th Street SE, Minneapolis, MN 55455, USA.
Orchard PJ; Division of Pediatric Blood and Marrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, 425 East River Parkway, Minneapolis, MN 55455, USA.
Cloyd JC; Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 2001 6th Street SE, Minneapolis, MN 55455, USA.
Kartha RV; Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 2001 6th Street SE, Minneapolis, MN 55455, USA.

Biomedicines ; 9(12)2021 Dec 03.

Article em En | MEDLINE | ID: mdl-34944641

Palavras-chave

N-acetylcysteine (NAC); adrenoleukodystrophy (ALD); antioxidant; glutathione (GSH); mitochondrial GSH (mtGSH); mitochondrial dysfunction; oligodendrocytes; very long-chain fatty acids (VLCFA)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomedicines Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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