Radiosensitizer Effect of ß-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis.

Kwon, Jin-Hee; Lee, Na-Gyeong; Kang, A-Ram; Song, Jie-Young; Hwang, Sang-Gu; Um, Hong-Duck; Kim, Joon; Park, Jong Kuk

Kwon, Jin-Hee; Lee, Na-Gyeong; Kang, A-Ram; Song, Jie-Young; Hwang, Sang-Gu; Um, Hong-Duck; Kim, Joon; Park, Jong Kuk.

Afiliação

Kwon JH; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Lee NG; Division of Life Sciences, Korea University, Seoul 02841, Korea.
Kang AR; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Song JY; Division of Life Sciences, Korea University, Seoul 02841, Korea.
Hwang SG; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Um HD; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Kim J; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Park JK; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.

Int J Mol Sci ; 22(24)2021 Dec 16.

Article em En | MEDLINE | ID: mdl-34948311

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Neoplasias Colorretais/tratamento farmacológico; Podofilina/farmacologia; Radiossensibilizantes/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Animais; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Neoplasias Colorretais/metabolismo; Células HCT116; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

Palavras-chave

ROS; apoptosis; colorectal cancer; radiosensitizer; topoisomerase inhibitor; ß-apopicropodophyllin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Podofilina / Radiossensibilizantes / Neoplasias Colorretais / Espécies Reativas de Oxigênio / Apoptose / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article

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