RNA synthesis inhibitors on young rat adrenal in primary culture. An ultrastructural study.
Tissue Cell
; 19(2): 167-75, 1987.
Article
em En
| MEDLINE
| ID: mdl-3495905
ABSTRACT
Adrenal cells of newborn rat adrenals in primary tissue culture were treated with actinomycin D (2, 10 and 25 micrograms/ml), alpha-amanitin (5 and 50 micrograms/ml) and cordycepin (100 micrograms/ml) and studied with the electron microscope. The most striking changes observed with the three drugs were localized on the nucleoli, and consisted, respectively, of segregation (actinomycin D), fragmentation (alpha-amanitin) and microsegregation (cordycepin). These results are consistent with the molecular sites of action of the drugs and are comparable to previous in vivo findings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desoxiadenosinas
/
Glândulas Suprarrenais
/
Dactinomicina
/
Amanitinas
Limite:
Animals
Idioma:
En
Revista:
Tissue Cell
Ano de publicação:
1987
Tipo de documento:
Article