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Recent progress of macrophage vesicle-based drug delivery systems.
Xu, Wen-Jie; Cai, Jia-Xin; Li, Yong-Jiang; Wu, Jun-Yong; Xiang, Daxiong.
Afiliação
  • Xu WJ; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Cai JX; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.
  • Li YJ; Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug, Hunan Province, Changsha, China.
  • Wu JY; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Xiang D; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.
Drug Deliv Transl Res ; 12(10): 2287-2302, 2022 10.
Article em En | MEDLINE | ID: mdl-34984664
Nanoparticle drug delivery systems (NDDSs) are promising platforms for efficient delivery of drugs. In the past decades, many nanomedicines have received clinical approval and completed translation. With the rapid advance of nanobiotechnology, natural vectors are emerging as novel strategies to carry and delivery nanoparticles and drugs for biomedical applications. Among diverse types of cells, macrophage is of great interest for their essential roles in inflammatory and immune responses. Macrophage-derived vesicles (MVs), including exosomes, microvesicles, and those from reconstructed membranes, may inherit the chemotactic migration ability and high biocompatibility. The unique properties of MVs make them competing candidates as novel drug delivery systems for precision nanomedicine. In this review, the advantages and disadvantages of existing NDDSs and MV-based drug delivery systems (MVDDSs) were compared. Then, we summarized the potential applications of MVDDSs and discuss future perspectives. The development of MVDDS may provide avenues for the treatment of diseases involving an inflammatory process.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Micropartículas Derivadas de Células Idioma: En Revista: Drug Deliv Transl Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Micropartículas Derivadas de Células Idioma: En Revista: Drug Deliv Transl Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China