Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen.
Science
; 238(4834): 1704-7, 1987 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-3500514
ABSTRACT
The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Linfócitos T
/
Antígenos de Diferenciação de Linfócitos T
/
Proteínas do Envelope Viral
/
HIV
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1987
Tipo de documento:
Article