Risk factors associated with unsuccessful tuberculosis treatment outcomes in Hunan Province, China.
Trop Med Int Health
; 27(3): 290-299, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-35014123
ABSTRACT
OBJECTIVES:
Globally, China has the third highest number of tuberculosis (TB) cases despite high rates (85.6%) of effective treatment coverage. Identifying risk factors associated with unsuccessful treatment outcomes is an important component of maximising the efficacy of TB control programmes.METHODS:
Retrospective cohort study to evaluate the outcomes of 306,860 drug-susceptible TB patients who underwent treatment in Hunan Province, China between 2013 and 2018. Univariable and multivariable logistic regression models were used to identify factors associated with unsuccessful TB treatment outcomes.RESULTS:
A successful treatment outcome was recorded for 98.6% of patients, defined as the sum of patients who were cured (36.2%) and completed treatment (62.4%). An unsuccessful treatment outcome was recorded for 1.8% of patients, defined as the sum of treatment failure (1.1%), deaths (0.5%) and lost to follow up (0.2%). The odds of an unsuccessful treatment outcome showed an increasing trend in more recent years of registration (2018 adjusted odds ratio (AOR) 1.43; 95% Confidence Interval (CI) 1.31, 1.57 relative to 2013). Other significant risk factors were male sex (AOR 1.17; 95% CI 1.10, 1.25); increasing age (AOR1.02 per year increase; 95% CI 1.02,1.02); being severely ill (AOR 1.50; 95% CI 1.33, 1.70); having a history of TB treatment (AOR 2.93; 95% CI 2.69, 3.20); not being under systematic management (AOR 16.10 (14.49, 17.88) and treatment regimens that differed from full course management.CONCLUSIONS:
The increasing likelihood of an unsuccessful treatment outcome over time necessitates the need for further research.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Antituberculosos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Trop Med Int Health
Assunto da revista:
MEDICINA TROPICAL
/
SAUDE PUBLICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Austrália