Glycyrrhiza uralensis root extract ameliorates high glucose-induced renal proximal tubular fibrosis by attenuating tubular epithelial-myofibroblast transdifferentiation by targeting TGF-ß1/Smad/Stat3 pathway.

Lin, Henry Cherng-Han; Paul, Catherine Reena; Kuo, Chia-Hua; Chang, Yung-Hsien; Chen, William Shao-Tsu; Ho, Tsung-Jung; Day, Cecilia-Hsuan; Velmurugan, Bharath Kumar; Tsai, Yuhsin; Huang, Chih-Yang

Lin, Henry Cherng-Han; Paul, Catherine Reena; Kuo, Chia-Hua; Chang, Yung-Hsien; Chen, William Shao-Tsu; Ho, Tsung-Jung; Day, Cecilia-Hsuan; Velmurugan, Bharath Kumar; Tsai, Yuhsin; Huang, Chih-Yang.

Afiliação

Lin HC; Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
Paul CR; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Hualien, Taiwan.
Kuo CH; Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Chang YH; Department of Chinese Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Chen WS; Department of Psychiatry, Tzu Chi General Hospital, Hualien, Taiwan.
Ho TJ; School of Medicine, Tzu Chi University, Hualien, Taiwan.
Day CH; Department of Chinese Medicine, Hualien Tzu Chi Hospital, Tzu Chi University, Hualien, Taiwan.
Velmurugan BK; Integration Center of Traditional Chinese and Modern Medicine, HualienTzu Chi Hospital, Hualien, Taiwan.
Tsai Y; School of Post-Baccalaure-ate Chinese Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan.
Huang CY; Department of Nursing, MeiHo University, Pingtung, Taiwan.

J Food Biochem ; 46(5): e14041, 2022 05.

Article em En | MEDLINE | ID: mdl-35064587

Assuntos

Nefropatias Diabéticas; Medicamentos de Ervas Chinesas; Glycyrrhiza uralensis; Animais; Linhagem Celular; Transdiferenciação Celular; Nefropatias Diabéticas/tratamento farmacológico; Nefropatias Diabéticas/metabolismo; Medicamentos de Ervas Chinesas/farmacologia; Fibrose; Glucose; Glycyrrhiza uralensis/química; Humanos; Camundongos; Miofibroblastos/metabolismo; Extratos Vegetais/farmacologia; Transdução de Sinais; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

Glycyrrhizae Radix; diabetic nephropathy; fibrosis; inflammation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Glycyrrhiza uralensis / Nefropatias Diabéticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Food Biochem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google