Your browser doesn't support javascript.
loading
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal.
Nishizawa, Hironari; Yamanaka, Mie; Igarashi, Kazuhiko.
Afiliação
  • Nishizawa H; Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Yamanaka M; Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Igarashi K; Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
FEBS J ; 290(7): 1688-1704, 2023 04.
Article em En | MEDLINE | ID: mdl-35107212
ABSTRACT
Ferroptosis is triggered by a chain of intracellular labile iron-dependent peroxidation of cell membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and neurodegenerative diseases but also as a mechanism of cancer suppression, and a better understanding of its regulatory mechanism is required. It has become clear that ferroptosis is finely controlled by two oxidative stress-responsive transcription factors, NRF2 (NF-E2-related factor 2) and BACH1 (BTB and CNC homology 1). NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway. In addition to this, NRF2 and BACH1 control ferroptosis through the regulation of lipid metabolism and cell differentiation. This multifaceted regulation of ferroptosis by NRF2 and BACH1 is considered to have been acquired during the evolution of multicellular organisms, allowing the utilization of ferroptosis for maintaining homeostasis, including cancer suppression. In terms of cell-cell interaction, it has been revealed that ferroptosis has the property of propagating to surrounding cells along with lipid peroxidation. The regulation of ferroptosis by NRF2 and BACH1 and the propagation phenomenon could be used to realize anticancer cell therapy in the future. In this review, these points will be summarized and discussed.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose / Neoplasias Limite: Humans Idioma: En Revista: FEBS J Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose / Neoplasias Limite: Humans Idioma: En Revista: FEBS J Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão