Evolution of Imipenem-Relebactam Resistance Following Treatment of Multidrug-Resistant Pseudomonas aeruginosa Pneumonia.

Shields, Ryan K; Stellfox, Madison E; Kline, Ellen G; Samanta, Palash; Van Tyne, Daria

Shields, Ryan K; Stellfox, Madison E; Kline, Ellen G; Samanta, Palash; Van Tyne, Daria.

Afiliação

Shields RK; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Stellfox ME; XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Kline EG; Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Samanta P; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Van Tyne D; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Clin Infect Dis ; 75(4): 710-714, 2022 09 10.

Article em En | MEDLINE | ID: mdl-35136967

ABSTRACT

ABSTRACT

We report the emergence of imipenem-relebactam nonsusceptible Pseudomonas aeruginosa in 5 patients treated for nosocomial pneumonia for 10-28 days. Genome sequence analysis identified treatment-emergent mutations in MexAB-OprM and/or MexEF-OprN efflux operons that arose independently in each patient across distinct P. aeruginosa sequence types. Testing with efflux-inhibitor PAßN restored imipenem-relebactam susceptibility.

Assuntos

Pneumonia; Pseudomonas aeruginosa; Antibacterianos/farmacologia; Antibacterianos/uso terapêutico; Compostos Azabicíclicos; Humanos; Imipenem/farmacologia; Imipenem/uso terapêutico; Testes de Sensibilidade Microbiana; Pseudomonas aeruginosa/genética

Palavras-chave

Pseudomonas; ceftolozane-tazobactam; efflux; imipenem-relebactam; resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Pseudomonas aeruginosa Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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