Reckoning apigenin and kaempferol as a potential multi-targeted inhibitor of EGFR/HER2-MEK pathway of metastatic colorectal cancer identified using rigorous computational workflow.

Sharma, Abhilasha; Sinha, Sonam; Rathaur, Pooja; Vora, Jaykant; Jha, Prakash C; Johar, Kaid; Rawal, Rakesh M; Shrivastava, Neeta

Sharma, Abhilasha; Sinha, Sonam; Rathaur, Pooja; Vora, Jaykant; Jha, Prakash C; Johar, Kaid; Rawal, Rakesh M; Shrivastava, Neeta.

Afiliação

Sharma A; B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, Gujarat, India.
Sinha S; Department of Biochemistry & Forensic Science, University School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
Rathaur P; Department of Life Science, University School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
Vora J; B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, Gujarat, India.
Jha PC; Kashiv Biosciences, FP 27/2,43, TP-86, BLOCK-B OPP. Apple Woods Township, SP Ring Road, 382210, Ahmedabad, Gujarat, India.
Johar K; Department of Life Science, University School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
Rawal RM; Department of Zoology, Biomedical Technology, and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
Shrivastava N; B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, Gujarat, India.

Mol Divers ; 26(6): 3337-3356, 2022 Dec.

Article em En | MEDLINE | ID: mdl-35147860

Assuntos

Antineoplásicos; Neoplasias Colorretais; Humanos; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apigenina/farmacologia; Apigenina/uso terapêutico; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Resistencia a Medicamentos Antineoplásicos; Receptores ErbB; Quempferóis/farmacologia; Quempferóis/uso terapêutico; Quinases de Proteína Quinase Ativadas por Mitógeno/farmacologia; Quinases de Proteína Quinase Ativadas por Mitógeno/uso terapêutico; Simulação de Acoplamento Molecular; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

Apigenin; CAM assay; Colorectal cancer; Computer-aided drug discovery; EGFR resistance; Kaempferol; Multi-targeted approach; Network pharmacology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Divers Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

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