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Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia.
Zazhytska, Marianna; Kodra, Albana; Hoagland, Daisy A; Frere, Justin; Fullard, John F; Shayya, Hani; McArthur, Natalie G; Moeller, Rasmus; Uhl, Skyler; Omer, Arina D; Gottesman, Max E; Firestein, Stuart; Gong, Qizhi; Canoll, Peter D; Goldman, James E; Roussos, Panos; tenOever, Benjamin R; Lomvardas, Stavros.
Afiliação
  • Zazhytska M; Mortimer B. Zuckerman Mind, and Brain and Behavior Institute, Columbia University, New York, NY 10027, USA.
  • Kodra A; Mortimer B. Zuckerman Mind, and Brain and Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Genetics and Development, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Hoagland DA; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA.
  • Frere J; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA.
  • Fullard JF; Center for Disease Neurogenomics, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mt. Sina
  • Shayya H; Mortimer B. Zuckerman Mind, and Brain and Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Genetics and Development, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • McArthur NG; Department of Biological Sciences, Columbia University New York, NY 10027, USA.
  • Moeller R; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA.
  • Uhl S; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA.
  • Omer AD; Baylor Genetics, 2450 Holcombe Blvd, Houston, TX 77021, USA.
  • Gottesman ME; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Firestein S; Department of Biological Sciences, Columbia University New York, NY 10027, USA.
  • Gong Q; Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, Davis, CA 95616, USA.
  • Canoll PD; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Goldman JE; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Roussos P; Center for Disease Neurogenomics, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mt. Sina
  • tenOever BR; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY 10029, USA. Electronic address: benjamin.tenoever@nyulangone.edu.
  • Jonathan B Overdevest; Department of Otolaryngology, Head and Neck Surgery, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: jo2566@cumc.columbia.edu.
  • Lomvardas S; Mortimer B. Zuckerman Mind, and Brain and Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electr
Cell ; 185(6): 1052-1064.e12, 2022 03 17.
Article em En | MEDLINE | ID: mdl-35180380
ABSTRACT
SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage in a variety of organs. Thus, deciphering the non-cell-autonomous effects of SARS-CoV-2 infection is imperative for understanding the cellular and molecular disruption it elicits. Neurological and cognitive defects are among the least understood symptoms of COVID-19 patients, with olfactory dysfunction being their most common sensory deficit. Here, we show that both in humans and hamsters, SARS-CoV-2 infection causes widespread downregulation of olfactory receptors (ORs) and of their signaling components. This non-cell-autonomous effect is preceded by a dramatic reorganization of the neuronal nuclear architecture, which results in dissipation of genomic compartments harboring OR genes. Our data provide a potential mechanism by which SARS-CoV-2 infection alters the cellular morphology and the transcriptome of cells it cannot infect, offering insight to its systemic effects in olfaction and beyond.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anosmia / COVID-19 Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anosmia / COVID-19 Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos