[A new pathophysiological element in severe asthma: GTPase Rac]. / Un nouvel acteur physiopathologique dans l'asthme sévère : la GTPase Rac.
Rev Mal Respir
; 39(2): 100-103, 2022 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-35183407
ABSTRACT
Asthma is a chronic airway condition defined by hyperresponsiveness, bronchial remodeling and chronic inflammation. A significant proportion of severe asthmatic patients remain uncontrolled despite recent therapeutic breakthroughs (biotherapies). Better understanding of the signaling pathways involved in the pathophysiological mechanisms underlying severe asthma could successfully address this unmet need. Rac GTPase acts as a molecular switch and has already been convincingly associated with airway hyperresponsiveness and bronchial remodeling in asthma. Having been elucidated by acquired knowledge regarding other pathologies. Its role in the inflammation mechanisms characterizing asthma is currently under specific evaluation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade Respiratória
/
Asma
/
GTP Fosfo-Hidrolases
Limite:
Humans
Idioma:
Fr
Revista:
Rev Mal Respir
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França