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Host-Assisted Delivery of a Model Drug to Genomic DNA: Key Information from Ultrafast Spectroscopy and in silico Study.
Ghosh, Ria; Singh, Soumendra; Mukherjee, Dipanjan; Mondal, Susmita; Das, Monojit; Pal, Uttam; Adhikari, Aniruddha; Bhushan, Aman; Bose, Surajit; Bhattacharyya, Siddharth Sankar; Pal, Debasish; Saha-Dasgupta, Tanusri; Bhattacharyya, Maitree; Bhattacharyya, Debasis; Mallick, Asim Kumar; Das, Ranjan; Pal, Samir Kumar.
Afiliação
  • Ghosh R; Department of Chemical Biological and Macromolecular Sciences, S.N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt lake, Kolkata 700106, India.
  • Singh S; Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Rd, Ballygunge, Kolkata 700019, India.
  • Mukherjee D; Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India.
  • Mondal S; Department of Chemical Biological and Macromolecular Sciences, S.N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt lake, Kolkata 700106, India.
  • Das M; Department of Chemical Biological and Macromolecular Sciences, S.N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt lake, Kolkata 700106, India.
  • Pal U; Department of Zoology, Uluberia College, University of Calcutta, Howrah, 711315, India.
  • Adhikari A; Department of Zoology, Vidyasagar University, Midnapore, 721102, India.
  • Bhushan A; Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India.
  • Bose S; Department of Chemical Biological and Macromolecular Sciences, S.N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt lake, Kolkata 700106, India.
  • Bhattacharyya SS; Department of Biotechnology, Thapar Institute of Engineering and Technology, Bhadson Road, Patiala, Punjab 147004, India.
  • Pal D; Department of Oral and Maxillofacial Pathology, KSDJ Dental College and Hospital, 700002, Kolkata, India.
  • Saha-Dasgupta T; Department of Zoology, Uluberia College, University of Calcutta, Howrah, 711315, India.
  • Bhattacharyya M; Department of Zoology, Uluberia College, University of Calcutta, Howrah, 711315, India.
  • Bhattacharyya D; Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India.
  • Mallick AK; Department of Condensed Matter Physics and Material Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, 700106, India.
  • Das R; Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Rd, Ballygunge, Kolkata 700019, India.
  • Pal SK; Department of Gynecology & Obstetrics, Nil Ratan Sircar Medical College & Hospital, 138, AJC Bose Road, Sealdah, Raja Bazar, Kolkata, 700014, India.
Chembiochem ; 23(9): e202200109, 2022 05 04.
Article em En | MEDLINE | ID: mdl-35225409
ABSTRACT
Drug delivery to a target without adverse effects is one of the major criteria for clinical use. Herein, we have made an attempt to explore the delivery efficacy of SDS surfactant in a monomer and micellar stage during the delivery of the model drug, Toluidine Blue (TB) from the micellar cavity to DNA. Molecular recognition of pre-micellar SDS encapsulated TB with DNA occurs at a rate constant of k1 ∼652 s-1 . However, no significant release of encapsulated TB at micellar concentration was observed within the experimental time frame. This originated from the higher binding affinity of TB towards the nano-cavity of SDS at micellar concentration which does not allow the delivery of TB from the nano-cavity of SDS micelles to DNA. Thus, molecular recognition controls the extent of DNA recognition by TB which in turn modulates the rate of delivery of TB from SDS in a concentration-dependent manner.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Micelas Tipo de estudo: Prognostic_studies Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Micelas Tipo de estudo: Prognostic_studies Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia