Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.

Shams, Hengameh; Shao, Xiaorong; Santaniello, Adam; Kirkish, Gina; Harroud, Adil; Ma, Qin; Isobe, Noriko; Schaefer, Catherine A; McCauley, Jacob L; Cree, Bruce A C; Didonna, Alessandro; Baranzini, Sergio E; Patsopoulos, Nikolaos A; Hauser, Stephen L; Barcellos, Lisa F; Henry, Roland G; Oksenberg, Jorge R

Shams, Hengameh; Shao, Xiaorong; Santaniello, Adam; Kirkish, Gina; Harroud, Adil; Ma, Qin; Isobe, Noriko; Schaefer, Catherine A; McCauley, Jacob L; Cree, Bruce A C; Didonna, Alessandro; Baranzini, Sergio E; Patsopoulos, Nikolaos A; Hauser, Stephen L; Barcellos, Lisa F; Henry, Roland G; Oksenberg, Jorge R.

Afiliação

Shams H; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Shao X; Division of Epidemiology and Biostatistics, School of Public Health, University of California Berkeley, Berkeley, CA 94720, USA.
Santaniello A; Division of Epidemiology and Biostatistics, School of Public Health, University of California Berkeley, Berkeley, CA 94720, USA.
Kirkish G; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Harroud A; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Ma Q; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Isobe N; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
McCauley JL; Kaiser Permanente Division of Research, Oakland, CA 94612, USA.
Cree BAC; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Didonna A; Dr. John T. Macdonald Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Baranzini SE; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Patsopoulos NA; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Hauser SL; Department of Anatomy and Cell Biology, East Carolina University, Greenville, NC 27834, USA.
Barcellos LF; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Henry RG; Systems Biology and Computer Science Program, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, 02115 MA, USA.
Oksenberg JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Brain ; 146(2): 645-656, 2023 02 13.

Article em En | MEDLINE | ID: mdl-35253861

Assuntos

Estudo de Associação Genômica Ampla; Esclerose Múltipla; Humanos; Herança Multifatorial/genética; Esclerose Múltipla/genética; Epigênese Genética; População Europeia; Fatores de Risco; Predisposição Genética para Doença/genética; Fenótipo

Palavras-chave

multiple sclerosis; pathway-specific risk score; phenotype association; polygenic risk score

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Esclerose Múltipla Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Brain Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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