Association Between Atopic Dermatitis, Asthma, and Serum Lipids: A UK Biobank Based Observational Study and Mendelian Randomization Analysis.
Front Med (Lausanne)
; 9: 810092, 2022.
Article
em En
| MEDLINE
| ID: mdl-35265637
ABSTRACT
Background:
Both atopic diseases and dysregulation of serum lipids (SLs) add to significant health burden, but evidences about their association are inconsistent.Objective:
This work is to evaluate the association between asthma/atopic dermatitis (AD) and SLs and investigate the potential causal relationship.Methods:
A large-scale cross-sectional study based on the UK Biobank (UKB) and then examined the casual relationships between SLs with asthma/AD based on a Mendelian randomization (MR) analysis.Results:
A total of 502,505 participants were included in analysis. After full adjustment, AD was associated with lower TG (ß = -0.006; 95%CI, -0.010 to -0.002; P = 0.006), lower LDL (ß = -0.004; 95%CI, -0.006 to -0.002, P < 0.001), and lower TC (ß = -0.004; 95%CI, -0.005 to -0.002; P < 0.001) but insignificantly correlated to HDL (P = 0.794). Asthma was also inversely correlated to TG (ß = -0.005; 95%CI, = -0.007 to -0.003; < 0.001), LDL (ß = -0.003; 95%CI, -0.004 to -0.002; P < 0.001), and TC (ß = -0.002; 95%CI, -0.003 to -0.002; P < 0.001), but was positively correlated to HDL (ß = 0.004; 95%CI, 0.003 to 0.005; P < 0.001), respectively. In subsequent MR analysis, both allergic diseases and asthma showed a protective effect on TC. Allergic diseases, asthma, and AD all showed a negative effect on LDL.Conclusion:
Collectively, we identify a protective causal effect of allergic diseases on serum lipids, as well as a potentially positive association of HDL with asthma. Owing to the largest sample size and the application of IVs in causal inference, this study will provide a robust evidence for the management of asthma and AD and the prevention of dyslipidemia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Front Med (Lausanne)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China