Mapping Mechanistic Pathways of Acute Oral Systemic Toxicity Using Chemical Structure and Bioactivity Measurements.

Edwards, Stephen W; Nelms, Mark; Hench, Virginia K; Ponder, Jessica; Sullivan, Kristie

Edwards, Stephen W; Nelms, Mark; Hench, Virginia K; Ponder, Jessica; Sullivan, Kristie.

Afiliação

Edwards SW; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, Durham, NC, United States.
Nelms M; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, Durham, NC, United States.
Hench VK; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, Durham, NC, United States.
Ponder J; Physicians Committee for Responsible Medicine, Washington, DC, United States.
Sullivan K; Physicians Committee for Responsible Medicine, Washington, DC, United States.

Front Toxicol ; 4: 824094, 2022.

Article em En | MEDLINE | ID: mdl-35295211

Palavras-chave

acute oral systemic toxicity; adverse outcome pathway; chemical structure-based clustering; in vitro bioactivity assays; new alternative methods; tiered testing; tiered testing strategy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Toxicol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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