The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.
Annu Rev Biochem
; 91: 571-598, 2022 06 21.
Article
em En
| MEDLINE
| ID: mdl-35303793
ABSTRACT
The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the generation and spatial arrangement of distinct cell types. By regulating cell fate specification, mitotic activity, and cell polarity, Wnt signaling orchestrates development and tissue homeostasis, and its dysregulation is implicated in developmental defects, cancer, and degenerative disorders. We review advances in our understanding of this key pathway, from Wnt protein production and secretion to relay of the signal in the cytoplasm of the receiving cell. We discuss the evolutionary history of this pathway as well as endogenous and synthetic modulators of its activity. Finally, we highlight remaining gaps in our knowledge of Wnt signal transduction and avenues for future research.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Via de Sinalização Wnt
/
Neoplasias
Limite:
Animals
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2022
Tipo de documento:
Article