Double life: How GRK2 and ß-arrestin signaling participate in diseases.
Cell Signal
; 94: 110333, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35430346
ABSTRACT
G-protein coupled receptor (GPCR) kinases (GRKs) and ß-arrestins play key roles in GPCR and non-GPCR cellular responses. In fact, GRKs and arrestins are involved in a plethora of pathways vital for physiological maintenance of inter- and intracellular communication. Here we review decades of research literature spanning from the discovery, identification of key structural elements, and findings supporting the diverse roles of these proteins in GPCR-mediated pathways. We then describe how GRK2 and ß-arrestins partake in non-GPCR signaling and briefly summarize their involvement in various pathologies. We conclude by presenting gaps in knowledge and our prospective on the promising pharmacological potential in targeting these proteins and/or downstream signaling. Future research is warranted and paramount for untangling these novel and promising roles for GRK2 and arrestins in metabolism and disease progression.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arrestinas
/
Quinases de Receptores Acoplados a Proteína G
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Cell Signal
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos