Lipid A Mimetics Based on Unnatural Disaccharide Scaffold as Potent TLR4 Agonists for Prospective Immunotherapeutics and Adjuvants.

Strobl, Sebastian; Hofbauer, Karin; Heine, Holger; Zamyatina, Alla

Strobl, Sebastian; Hofbauer, Karin; Heine, Holger; Zamyatina, Alla.

Afiliação

Strobl S; Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, 1190, Austria.
Hofbauer K; Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, 1190, Austria.
Heine H; Research Group Innate Immunity, Research Center Borstel-Leibniz Lung Center, Airway Research Center North (ARCN), German Center for Lung Disease (DZL), Parkallee 22, Borstel, 23845, Germany.
Zamyatina A; Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, 1190, Austria.

Chemistry ; 28(35): e202200547, 2022 Jun 21.

Article em En | MEDLINE | ID: mdl-35439332

Assuntos

Lipídeo A; Receptor 4 Toll-Like; Adjuvantes Imunológicos/química; Animais; Dissacarídeos/química; Humanos; Imunoterapia; Lipídeo A/química; Camundongos; Estudos Prospectivos; Receptor 4 Toll-Like/agonistas

Palavras-chave

adjuvant; carbohydrates; glycosylation; lipopolysaccharide; modulation of the innate immune responses

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 4 Toll-Like / Lipídeo A Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Áustria

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