Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase.

Koike, Hiroshi; Nishida, Yoshihiro; Shinomura, Tamayuki; Ohkawara, Bisei; Ohno, Kinji; Zhuo, Lisheng; Kimata, Koji; Ushida, Takahiro; Imagama, Shiro

Koike, Hiroshi; Nishida, Yoshihiro; Shinomura, Tamayuki; Ohkawara, Bisei; Ohno, Kinji; Zhuo, Lisheng; Kimata, Koji; Ushida, Takahiro; Imagama, Shiro.

Afiliação

Koike H; Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
Nishida Y; Department of Rehabilitation Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
Shinomura T; Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Ohkawara B; Center for Neurological Diseases and Cancer, Division of Neurogenetics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
Ohno K; Center for Neurological Diseases and Cancer, Division of Neurogenetics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
Zhuo L; Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
Kimata K; Multidisciplinary Pain Center, Aichi Medical University, Nagakute 480-1195, Japan.
Ushida T; Multidisciplinary Pain Center, Aichi Medical University, Nagakute 480-1195, Japan.
Imagama S; Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.

Int J Mol Sci ; 23(8)2022 Apr 07.

Article em En | MEDLINE | ID: mdl-35456905

Assuntos

Artrite Experimental; Sinoviócitos; Animais; Artrite Experimental/tratamento farmacológico; Artrite Experimental/metabolismo; Reposicionamento de Medicamentos; Fibroblastos/metabolismo; Ácido Hialurônico/farmacologia; Hialuronoglucosaminidase/metabolismo; Isoflavonas; Metaloproteinase 1 da Matriz/genética; Metaloproteinase 1 da Matriz/metabolismo; Camundongos; Ratos; Sinoviócitos/metabolismo

Palavras-chave

CEMIP; KIAA1199; collagen-induced arthritis; hyaluronan; hyaluronidase; inflammatory arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Sinoviócitos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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