Efficacy of first-line immune checkpoint inhibitors in patients with advanced NSCLC with KRAS, MET, FGFR, RET, BRAF, and HER2 alterations.
Thorac Cancer
; 13(11): 1703-1711, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35491960
ABSTRACT
BACKGROUND:
In patients with non-small cell lung cancer (NSCLC) harboring driver alterations, the efficacy of immune checkpoint inhibitors (ICIs) remains uncertain. Our study aimed to examine the first-line ICI efficacy in patients with NSCLC harboring KRAS, MET, FGFR, RET, BRAF, and HER2 alterations in a real-world setting.METHODS:
This single-center, retrospective cohort study included patients with advanced NSCLC harboring KRAS, MET, FGFR, RET, BRAF, HER2 alterations or driver-negative, and were treated with first-line ICI therapy. Best overall response, progression-free survival (PFS), and overall survival (OS) were evaluated.RESULTS:
Seventy-eight patients with NSCLC were included (median age, 72 years) 67% were men, 15% were never-smokers, and 83% had adenocarcinoma. The driver alterations involved KRAS (n = 21), MET (n = 6), FGFR (n = 3), RET (n = 2), BRAF (n = 2), HER2 (n = 1), and driver-negative (n = 43). The partial responses for KRAS, MET, FGFR, RET, BRAF, HER2, and driver-negative were 57%, 50%, 100%, 50%, 100%, 0%, and 47%, respectively. The median PFS (months) was 16.2 (95% confidence interval [CI] 6.3- not reached [NR]) for KRAS, 2.8 (95% CI 2.7-NR) for MET, 11.7 (95% CI 5.9-NR) for other alterations (FGFR, RET, BRAF, and HER2), and 10.0 (95% CI 3.7-14.3) for driver-negative, respectively. The median OS (months) was 31.3 (95% CI 9.0-NR) for KRAS, not reached for MET, 23.5 (95% CI 18.3-NR) for other alterations, and 21.1 (95% CI 15.2-NR) for driver-negative, respectively.CONCLUSIONS:
The benefit of the first-line ICI was similar in advanced NSCLC regardless of the driver alterations, except for MET alterations.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Thorac Cancer
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão