&#945;-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.

Chen, Jia-Yue; Zhu, Qi; Cai, Cui-Zan; Luo, Hai-Bin; Lu, Jia-Hong

α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.

Chen, Jia-Yue; Zhu, Qi; Cai, Cui-Zan; Luo, Hai-Bin; Lu, Jia-Hong.

Afiliação

Chen JY; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
Zhu Q; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
Cai CZ; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
Luo HB; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China. Electronic address: hbluo@hainanu.edu.cn.
Lu JH; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China. Electronic address: jiahonglu@umac.mo.

Phytomedicine ; 101: 154125, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35525236

Assuntos

Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Doenças Neurodegenerativas; Doença de Parkinson; Inibidores da Fosfodiesterase 4; Animais; Neurônios Dopaminérgicos/metabolismo; Ativação Enzimática/efeitos dos fármacos; Humanos; Camundongos; Camundongos Transgênicos; Doenças Neurodegenerativas/metabolismo; Doença de Parkinson/metabolismo; Inibidores da Fosfodiesterase 4/metabolismo; Inibidores da Fosfodiesterase 4/farmacologia; Complexo de Endopeptidases do Proteassoma/metabolismo; Ratos; Ubiquitina/metabolismo; Xantonas; alfa-Sinucleína/metabolismo

Palavras-chave

Alpha-synuclein (α-syn); Parkinson's disease; Phosphodiesterase 4 inhibitor; Protein kinase A (PKA); ubiquitin-proteasome system (UPS)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Quinases Dependentes de AMP Cíclico / Doenças Neurodegenerativas / Inibidores da Fosfodiesterase 4 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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