Prime Editor 3 Mediated Beta-Thalassemia Mutations of the <i>HBB</i> Gene in Human Erythroid Progenitor Cells.

Zhang, Haokun; Zhou, Qinlinglan; Chen, Hongyan; Lu, Daru

Prime Editor 3 Mediated Beta-Thalassemia Mutations of the HBB Gene in Human Erythroid Progenitor Cells.

Zhang, Haokun; Zhou, Qinlinglan; Chen, Hongyan; Lu, Daru.

Afiliação

Zhang H; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Zhou Q; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Chen H; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Lu D; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.

Int J Mol Sci ; 23(9)2022 Apr 30.

Article em En | MEDLINE | ID: mdl-35563395

Assuntos

Células Precursoras Eritroides; Edição de Genes; Hemoglobinas; Talassemia beta; Células Precursoras Eritroides/metabolismo; Edição de Genes/métodos; Hemoglobinas/genética; Hemoglobinas/uso terapêutico; Humanos; Mutação; alfa-Globinas/genética; Globinas beta/genética; Talassemia beta/genética; Talassemia beta/terapia

Palavras-chave

HUDEP-2 cells; beta-thalassemia mutation; genome editing; prime editor 3; the HBB gene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas / Células Precursoras Eritroides / Talassemia beta / Edição de Genes Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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