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Risk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study.
Lin, Ro-Ting; Chen, Pei-Lung; Yang, Chi-Ying; Yeh, Chun-Chieh; Lin, Chun-Che; Huang, Wen-Hsin; Chung, An-Ko; Lin, Jaw-Town.
Afiliação
  • Lin RT; Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, 406040, Taiwan.
  • Chen PL; Department of Medical Genetics, National Taiwan University Hospital, Taipei, 100226, Taiwan.
  • Yang CY; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, 100025, Taiwan.
  • Yeh CC; Department of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, 404332, Taiwan.
  • Lin CC; Department of Surgery, China Medical University Hospital, Taichung, 404332, Taiwan.
  • Huang WH; Department of Surgery, Asia University Hospital, Taichung, 413505, Taiwan.
  • Chung AK; Department of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, 404332, Taiwan.
  • Lin JT; Department of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, 404332, Taiwan.
BMC Gastroenterol ; 22(1): 243, 2022 May 14.
Article em En | MEDLINE | ID: mdl-35568803
BACKGROUND: Increased pancreatic cancer incidence has been observed among younger than in older adults. This pilot study aimed to determine the feasibility of a large study that would compare the age at diagnosis of pancreatic cancer among patients with different risk factors. METHODS: We compared the age at diagnosis of pancreatic cancer between groups of pancreatic cancer patients exposed and not exposed to the identified risk factors. We estimated the age at which exposure started, average exposure quantity, and total years of exposure and investigated their relationships with age at diagnosis of pancreatic cancer. RESULTS: Sixteen out of 24 (67%) subjects carried known genetic factors and/or had smoking and/or drinking habits; however, an earlier age of pancreatic cancer diagnosis was not observed. Conversely, we found a significant correlation between the age at which alcohol consumption was started and the age at diagnosis of pancreatic cancer (r = 0.8124, P = 0.0043). CONCLUSIONS: Our pilot study suggested that a large study following this study design is feasible and that the following should be conducted in a large study: mediation analysis for disease-related factors, advanced genomic analysis for new candidate genes, and the correlation between age of first exposure to risk factors and pancreatic cancer onset.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: BMC Gastroenterol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: BMC Gastroenterol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan