Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical <i>S</i>-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.

Zhang, Jiawei; Hou, Xueli; Chen, Zhang; Ko, Yeonjin; Ruszczycky, Mark W; Chen, Yutian; Zhou, Jiahai; Liu, Hung-Wen

Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.

Zhang, Jiawei; Hou, Xueli; Chen, Zhang; Ko, Yeonjin; Ruszczycky, Mark W; Chen, Yutian; Zhou, Jiahai; Liu, Hung-Wen.

Afiliação

Zhang J; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Hou X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China.
Chen Z; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Ko Y; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Ruszczycky MW; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Chen Y; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
Zhou J; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
Liu HW; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

J Am Chem Soc ; 144(22): 9910-9919, 2022 06 08.

Article em En | MEDLINE | ID: mdl-35622017

Assuntos

Racemases e Epimerases; Espectinomicina; Cisteína; Oxirredutases; Filogenia; Racemases e Epimerases/genética; S-Adenosilmetionina/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectinomicina / Racemases e Epimerases Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google