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AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval.
Rekic, Dinko; Azarov, Ivan; Knöchel, Jane; Sokolov, Victor; Nilsson, Catarina; Wernevik, Linda; Han, David; Rydén-Bergsten, Tina; Ebrahimi, Ahmad; Dota, Corina; Carlsson, Björn.
Afiliação
  • Rekic D; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Azarov I; M&S Decisions LLC, Moscow, Russia.
  • Knöchel J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Sokolov V; M&S Decisions LLC, Moscow, Russia.
  • Nilsson C; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Wernevik L; Research and Early Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Han D; PAREXEL, Glendale, Los Angeles, CA, USA.
  • Rydén-Bergsten T; Research and Early Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Ebrahimi A; Cardiovascular Safety Center of Excellence, Global Patient Safety, Oncology R&D, Gothenburg, AZ, Sweden.
  • Dota C; Cardiovascular Safety Center of Excellence, Global Patient Safety, Oncology R&D, Gothenburg, AZ, Sweden.
  • Carlsson B; Research and Early Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Br J Clin Pharmacol ; 88(11): 4839-4844, 2022 11.
Article em En | MEDLINE | ID: mdl-35653229
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Síndrome do QT Longo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Síndrome do QT Longo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia