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Molecular Assessment of Staphylococcus Aureus Strains in STAT3 Hyper-IgE Syndrome Patients.
Schwierzeck, Vera; Effner, Renate; Abel, Felicitas; Reiger, Matthias; Notheis, Gundula; Held, Jürgen; Simon, Valeska; Dintner, Sebastian; Hoffmann, Reinhard; Hagl, Beate; Huebner, Johannes; Mellmann, Alexander; Renner, Ellen D.
Afiliação
  • Schwierzeck V; Translational Immunology in Environmental Medicine, School of Medicine, Technical University of Munich, 81675, Munich, Germany. vera.schwierzeck@ukmuenster.de.
  • Effner R; Institute of Environmental Medicine, Helmholtz Zentrum Munich, 85764, Neuherberg, Germany. vera.schwierzeck@ukmuenster.de.
  • Abel F; Institute of Hygiene, University Hospital Münster, 48149, Münster, Germany. vera.schwierzeck@ukmuenster.de.
  • Reiger M; Translational Immunology in Environmental Medicine, School of Medicine, Technical University of Munich, 81675, Munich, Germany.
  • Notheis G; Institute of Environmental Medicine, Helmholtz Zentrum Munich, 85764, Neuherberg, Germany.
  • Held J; Translational Immunology in Environmental Medicine, School of Medicine, Technical University of Munich, 81675, Munich, Germany.
  • Simon V; Institute of Environmental Medicine, Helmholtz Zentrum Munich, 85764, Neuherberg, Germany.
  • Dintner S; University Children's Hospital, Dr. von Haunersches Kinderspital, Ludwig Maximilian University, 80337, Munich, Germany.
  • Hoffmann R; Institute of Environmental Medicine, Helmholtz Zentrum Munich, 85764, Neuherberg, Germany.
  • Hagl B; Department of Environmental Medicine, Medical Faculty of University Augsburg, 86156, Augsburg, Germany.
  • Huebner J; Translational Immunology in Environmental Medicine, School of Medicine, Technical University of Munich, 81675, Munich, Germany.
  • Mellmann A; Institute of Environmental Medicine, Helmholtz Zentrum Munich, 85764, Neuherberg, Germany.
  • Renner ED; University Children's Hospital, Dr. von Haunersches Kinderspital, Ludwig Maximilian University, 80337, Munich, Germany.
J Clin Immunol ; 42(6): 1301-1309, 2022 08.
Article em En | MEDLINE | ID: mdl-35655107
Hyper-IgE syndromes (HIES) are a group of inborn errors of immunity (IEI) caused by monogenic defects such as in the gene STAT3 (STAT3-HIES). Patients suffering from HIES show an increased susceptibility to Staphylococcus aureus (S. aureus) including skin abscesses and pulmonary infections. To assess if the underlying immune defect of STAT3-HIES patients influences the resistance patterns, pathogenicity factors or strain types of S. aureus. We characterized eleven S. aureus strains isolated from STAT3-HIES patients (n = 4) by whole genome sequencing (WGS) to determine presence of resistance and virulence genes. Additionally, we used multi-locus sequence typing (MLST) and protein A (spa) typing to classify these isolates. Bacterial isolates collected from this cohort of STAT3-HIES patients were identified as common spa types in Germany. Only one of the isolates was classified as methicillin-resistant S. aureus (MRSA). For one STAT3 patient WGS illustrated that infection and colonization occurred with different S. aureus isolates rather than one particular clone. The identified S. aureus carriage profile on a molecular level suggests that S. aureus strain type in STAT3-HIES patients is determined by local epidemiology rather than the underlying immune defect highlighting the importance of microbiological assessment prior to antibiotic treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus Resistente à Meticilina / Síndrome de Job Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Clin Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus Resistente à Meticilina / Síndrome de Job Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Clin Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha