Protective effect of rutin and ß-cyclodextrin against hepatotoxicity and nephrotoxicity induced by lambda-cyhalothrin in Wistar rats: biochemical, pathological indices and molecular analysis.
Biomarkers
; 27(7): 625-636, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-35658761
ABSTRACT
BACKGROUND:
This study aimed to assess hepatotoxicity and nephrotoxicity of Lambda-cyhalothrin (LCT) and the protective effect of rutin alone and in combination with ß-cyclodextrin (ß-CD). MATERIALS ANDMETHODS:
Male Wistar rats were divided into five groups Group 1 was used as a control and received a standard diet and water. Group 2, 3, 4 and 5 were orally administered with LCT (7.6 mg/kg body weight), rutin (200 mg/kg body weight) LCT and rutin (at the same doses as in Group 2 and Group 3), and LCT and a mixture of rutin with ß-CD (400 mg/kg body weight), respectively. All experimental animals were orally gavaged 5 days/week for 60 days.RESULTS:
Our data revealed that LCT-induced liver and kidney injuries were related to the up-regulated expression of TNF-α and down-regulated expression of NRF-2 genes mRNA, whereas these effects were reversed with rutin treatment. LCT-induced oxidative stress altered the histological picture, and the hematological and biochemical parameters.CONCLUSION:
Treatment with a rutin-ß-CD complex had preventive potential against LCT via suppression of oxidative stress and augmentation of the antioxidant defense system.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Ciclodextrinas
/
Doença Hepática Induzida por Substâncias e Drogas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biomarkers
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Egito