A mathematical model of GLUT1 modulation in rods and RPE and its differential impact in cell metabolism.
Sci Rep
; 12(1): 10645, 2022 06 23.
Article
em En
| MEDLINE
| ID: mdl-35739198
ABSTRACT
We present a mathematical model of key glucose metabolic pathways in two cells of the human retina the rods and the retinal pigmented epithelium (RPE). Computational simulations of glucose transporter 1 (GLUT1) inhibition in the model accurately reproduce experimental data from conditional knockout mice and reveal that modification of GLUT1 expression levels of both cells differentially impacts their metabolism. We hypothesize that, under glucose scarcity, the RPE's energy producing pathways are altered in order to preserve its functionality, impacting the photoreceptors' outer segment renewal. On the other hand, when glucose is limited in the rods, aerobic glycolysis is preserved, which maintains the lactate contribution to the RPE.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Fotorreceptoras Retinianas Bastonetes
/
Transportador de Glucose Tipo 1
/
Epitélio Pigmentado da Retina
Limite:
Animals
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos