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Laboratory Diagnosis and In Vitro Antifungal Susceptibility of Trichophyton quinckeanum from Human Zoonoses and Cats.
Lagowski, Dominik; Gnat, Sebastian; Dylag, Mariusz; Nowakiewicz, Aneta.
Afiliação
  • Lagowski D; Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin, Poland.
  • Gnat S; Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin, Poland.
  • Dylag M; Department of Mycology and Genetics, Faculty of Biological Sciences, University of Wroclaw, 50-137 Wroclaw, Poland.
  • Nowakiewicz A; Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin, Poland.
Antibiotics (Basel) ; 11(6)2022 May 30.
Article em En | MEDLINE | ID: mdl-35740146
ABSTRACT
The "One Health" concept increasingly demonstrates the global spread of pathogenic (also eukaryotic) microorganisms and their zoonotic potential. Dermatophytes can cause superficial mycoses in humans and animals. Furthermore, the number of transmissions from asymptomatic carriers to humans has been on the rise over the last few years. This study was focused on the detailed characterisation of clinical isolates of Trichophyton quinckeanum with epidemiological analyses and characterisation of their in vitro antifungal susceptibility patterns. The isolated dermatophytes were identified with a combination of conventional and molecular methods. In turn, their susceptibility in vitro was tested according to the Clinical and Laboratory Standards Institute (CLSI) M38 ed.3 protocol. A total of 36 strains were isolated, with 21 cases of T. quinckeanum zoonoses resulting from direct contact with symptomatic cats (58.3%). The other 15 strains (41.7%) were isolated simultaneously from healthy cats and their owners. All strains showed high susceptibility to allylamine, pyridinone, and phenyl morpholine derivatives but were resistant to fluconazole and ketoconazole. In conclusion, our study shows the frequency of zoonoses contracted from asymptomatic cats. Moreover, the antifungal susceptibility profiles indicate the serious risk posed to animal owners by resistant strains of T. quinckeanum, which are often responsible for recalcitrant-to-treatment cases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Polônia