A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808.

Chung, Tae Kyu; Lee, Hyun A; Lee, Kyeong-Ryoon; Jang, Seong Bok; Yu, Kyung-Sang; Lee, Howard

Chung, Tae Kyu; Lee, Hyun A; Lee, Kyeong-Ryoon; Jang, Seong Bok; Yu, Kyung-Sang; Lee, Howard.

Afiliação

Chung TK; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Lee HA; Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Lee KR; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Jang SB; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Chungbuk, South Korea.
Yu KS; Department of Bioscience, University of Science and Technology, Daejeon, South Korea.
Lee H; Clinical Pharmacology Team, Clinical Development and Medical Department, Yuhan Corporation, Seoul, South Korea.

CPT Pharmacometrics Syst Pharmacol ; 11(9): 1223-1233, 2022 09.

Article em En | MEDLINE | ID: mdl-35748058

Assuntos

Antiulcerosos; Esomeprazol; Esomeprazol/análogos & derivados; Esomeprazol/farmacocinética; Retroalimentação; Humanos; Concentração de Íons de Hidrogênio; Masculino

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esomeprazol / Antiulcerosos Tipo de estudo: Clinical_trials Limite: Humans / Male Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul

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