Your browser doesn't support javascript.
loading
Neural Correlates of Optimal Deep Brain Stimulation for Cervical Dystonia.
Loh, Aaron; Elias, Gavin J B; Germann, Jürgen; Boutet, Alexandre; Gwun, Dave; Yamamoto, Kazuaki; Sarica, Can; Azevedo, Paula; Zemmar, Ajmal; Pinto, Jessica; Naheed, Asma; Kalia, Suneil K; Hodaie, Mojgan; Munhoz, Renato P; Lozano, Andres M; Fasano, Alfonso.
Afiliação
  • Loh A; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Elias GJB; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Germann J; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Boutet A; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Gwun D; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  • Yamamoto K; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Sarica C; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Azevedo P; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Zemmar A; Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Pinto J; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Naheed A; Department of Neurosurgery, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Henan University People's Hospital, Henan University School of Medicine, Zhengzhou, China.
  • Kalia SK; Department of Neurosurgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
  • Hodaie M; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  • Munhoz RP; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  • Lozano AM; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Fasano A; Krembil Research Institute, Toronto, Ontario, Canada.
Ann Neurol ; 92(3): 418-424, 2022 09.
Article em En | MEDLINE | ID: mdl-35785489
ABSTRACT
A total of 15 individuals with cervical dystonia and good outcome after pallidal deep brain stimulation underwent resting-state functional magnetic resonance imaging under three conditions stimulation using a priori clinically determined optimal settings (ON-Op), non-optimal settings (ON-NOp), and stimulation off (OFF). ON-Op > OFF and ON-Op > ON-NOp were both associated with significant deactivation within sensorimotor cortex (changes not seen with ON-NOp > OFF). Brain responses to stimulation were related to individual long-term clinical improvement (R = 0.73, R2 = 0.53, p = 0.001). The relationship was consistent when this model included four additional patients with generalized or truncal dystonia. These findings highlight the potential for immediate imaging-based biomarkers of clinical efficacy. ANN NEUROL 2022;92418-424.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Torcicolo / Estimulação Encefálica Profunda Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Ann Neurol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Torcicolo / Estimulação Encefálica Profunda Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Ann Neurol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá