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Hepatitis B RNA and Core-Related Antigen Provide Value Beyond DNA in Evaluating e But Not Surface Antigen Clearance.
King, Wendy C; Sterling, Richard K; Hinerman, Amanda S; Lok, Anna S F; Cloherty, Gavin A; Ghany, Marc G.
Afiliação
  • King WC; Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: kingw@edc.pitt.edu.
  • Sterling RK; Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
  • Hinerman AS; Epidemiology Department, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Lok ASF; Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.
  • Cloherty GA; Infectious Disease Research, Abbott Diagnostics, Abbott Park, Illinois.
  • Ghany MG; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Clin Gastroenterol Hepatol ; 21(7): 1957-1959, 2023 Jul.
Article em En | MEDLINE | ID: mdl-35850413
ABSTRACT
In chronic hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) clearance are important milestones toward immune control.1 A drop in HBV DNA is an established correlate of both HBeAg and HBsAg clearance.2 We evaluated changes in HBV RNA and hepatitis B core-related antigen (HBcrAg) levels, markers of transcriptional activity of covalently closed circular DNA (cccDNA),3,4 with HBeAg and HBsAg clearance, and compared them with changes in HBV DNA level among adult participants in the Hepatitis B Research Network (HBRN).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Hepatite B Limite: Adult / Humans Idioma: En Revista: Clin Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Hepatite B Limite: Adult / Humans Idioma: En Revista: Clin Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article