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High cysteine concentrations in cell culture media lead to oxidative stress and reduced bioprocess performance of recombinant CHO cells.
Komuczki, Daniel; Stadermann, Anna; Bentele, Maximilian; Unsoeld, Andreas; Grillari, Johannes; Mueller, Markus M; Paul, Albert; Fischer, Simon.
Afiliação
  • Komuczki D; Institute of Bioprocess Sciences and Engineering (IBSE), University of Natural Resources and Life Sciences, Vienna, Austria.
  • Stadermann A; Upstream Development, Bioprocess and Analytical Development, Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach a. d. Riss, Germany.
  • Bentele M; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach a. d. Riss, Germany.
  • Unsoeld A; Upstream Development, Bioprocess and Analytical Development, Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach a. d. Riss, Germany.
  • Grillari J; Cell Culture Media Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach a. d. Riss, Germany.
  • Mueller MM; Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
  • Paul A; Ludwig Boltzmann Institute for Traumatology. The Research Center in Cooperation with AUVA, Vienna, Austria.
  • Fischer S; Upstream Development, Bioprocess and Analytical Development, Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach a. d. Riss, Germany.
Biotechnol J ; 17(11): e2200029, 2022 Nov.
Article em En | MEDLINE | ID: mdl-35876277
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Cisteína Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biotechnol J Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Áustria
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Cisteína Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biotechnol J Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Áustria