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Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
Szychowski, Janek; Papp, Robert; Dietrich, Evelyne; Liu, Bingcan; Vallée, Frédéric; Leclaire, Marie-Eve; Fourtounis, Jimmy; Martino, Giovanni; Perryman, Alexander L; Pau, Victor; Yin, Shou Yun; Mader, Pavel; Roulston, Anne; Truchon, Jean-Francois; Marshall, C Gary; Diallo, Mohamed; Duffy, Nicole M; Stocco, Rino; Godbout, Claude; Bonneau-Fortin, Alexanne; Kryczka, Rosie; Bhaskaran, Vivek; Mao, Daniel; Orlicky, Stephen; Beaulieu, Patrick; Turcotte, Pascal; Kurinov, Igor; Sicheri, Frank; Mamane, Yael; Gallant, Michel; Black, W Cameron.
Afiliação
  • Szychowski J; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Papp R; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Dietrich E; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Liu B; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Vallée F; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Leclaire ME; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Fourtounis J; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Martino G; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Perryman AL; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Pau V; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.
  • Yin SY; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.
  • Roulston A; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Truchon JF; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Marshall CG; Repare Therapeutics, 1 Broadway, 15th Floor, Cambridge, Massachusetts 02142, United States.
  • Diallo M; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Duffy NM; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Stocco R; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Godbout C; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Bonneau-Fortin A; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Kryczka R; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Bhaskaran V; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Mao D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.
  • Orlicky S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.
  • Beaulieu P; OmegaChem Inc., 480 Rue Perreault, Saint-Romuald, QC G6W 7V6, Canada.
  • Turcotte P; AdMare BioInnovations, 7171 Frederick-Banting, Montréal, QC H4S 1Z9, Canada.
  • Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, Illinois 60439, United States.
  • Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.
  • Mamane Y; Departments of Biochemistry and Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada.
  • Gallant M; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
  • Black WC; Repare Therapeutics, Inc., 7210 Frederick-Banting, Ville St-Laurent, QC H4S 2A1, Canada.
J Med Chem ; 65(15): 10251-10284, 2022 08 11.
Article em En | MEDLINE | ID: mdl-35880755
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Neoplasias Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Neoplasias Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá