Facile synthesis of surface functionalized Pd2+@P-CDP/COFs for highly sensitive detection of norfloxacin drug based on the host-guest interaction.
J Pharm Biomed Anal
; 219: 114956, 2022 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-35882178
ABSTRACT
In this work, ß-cyclodextrin porous polymers (P-CDPs) functionalized novel covalent organic frameworks (P-CDPs/COFs) were synthesized by a simple and facile method. After combined with Pd2+ via electrostatic interaction, the Pd2+@P-CDPs/COFs nanocomposites were prepared and utilized as novel electrode materials to fabricate the non-enzyme electrochemical sensors for high-sensitivity detection of Norfloxacin (NF). Due to the host-guest recognition, excellent adsorption performance and catalytic performance of Pd2+@P-CDPs/COFs, the prepared sensor exhibited excellent electrochemical performance for detecting NF under the optimum conditions, which showed two linear ranges of 0.08-7.0 µM and 7.0-100.0 µM with a low detection limit of 0.031 µM (S/N = 3). Additionally, the obtained sensor has also been successfully applied to measure NF with satisfactory results in the real medicinal samples of NF eye-drops. Our findings paved the way for the development of COFs-based sensing platform in drug analysis and testing for human health, food security and the quality control of drugs.
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Texto completo:
1
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nanocompostos
/
Estruturas Metalorgânicas
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
2022
Tipo de documento:
Article