3' UTR, 3' untranslated region; ABCG1, ATP­binding cassette transporter G1; AKT, protein kinase B; AP-1, activating protein-1; BAX, BCL-2 associated X; BCL-2, B cell lymphoma-2; CCK-8, cell counting kit-8; CHOP, C/EBP homologous protein; COX-2, cyclooxygenase-2; CVDs, cardiovascular diseases; ChIP, chromatin immunoprecipitation; DMEM, Dulbecco's modified eagle's medium; ELISA, enzyme-linked immunosorbent assay; FBS, fetal bovine serum; GEN, genistein; Genistein; HSP90, heat shock protein 90; IF, immunofluorescence; IGF-1, insulin-like growth factor-1; IL-6, interleukin 6; Inflammatory response; JNK, c-Jun N-terminal kinase; LDH, lactate dehydrogenase; LPS, lipopolysaccharide; Lipopolysaccharide; MUT, mutant; Macrophage apoptosis; MyD88, myeloid differentiation primary response 88; NF-κB, nuclear factor-kappa B; PBMCs, peripheral blood mononuclear cells; PBS, phosphate buffered saline; PDCD4, programmed cell death 4; PDTC, pyrrolidine dithiocarbamate; PMφs, peritoneal macrophages; STAT3, signal transducer and activator of transcription 3; TIPE2, tumor necrosis factor-α-induced protein 8-like 2; TLR4, toll-like receptor 4; TNF-α, tumor necrosis factor-α; TRIF, Toll/IL-1R domain-containing adaptor-inducing IFN-ß; TiO2 NPs, titanium dioxide nanoparticles; Tumor necrosis factor-α-induced protein 8-like 2; WT, wild type; iNOS, inducible nitric oxide synthase; miR-21; qRT-PCR, quantitative real-time polymerase chain reaction