[Treatment of metastatic pancreatic cancer]. / Therapie des metastasierten Pankreaskarzinoms.
Inn Med (Heidelb)
; 63(8): 851-862, 2022 Aug.
Article
em De
| MEDLINE
| ID: mdl-35925070
ABSTRACT
Pancreatic cancer is the 4th most common cause of cancer death in Germany and continues to be associated with a poor prognosis. A prerequisite for chemotherapy or radiotherapy is always the pathohistological (or cytological) confirmation of the tumor disease. Molecular diagnostics include analysis of DNA mismatch repair in the tumor and of the germline mutations in BRCA 1/2 (gBRCA mutation). Systemic chemotherapy remains the mainstay in the management of locally advanced and metastatic disease. If a gBRCA mutation is detected, platinum-based therapy should be used. Patients with good performance status benefit from second-line therapy. Immunotherapy with checkpoint inhibitors (not yet approved) may be considered in pretreated patients with evidence of deficient DNA mismatch repair or microsatellite instability.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
Limite:
Humans
Idioma:
De
Revista:
Inn Med (Heidelb)
Ano de publicação:
2022
Tipo de documento:
Article