Ca2+-sensitizing effect of BM 14.478 on skinned cardiac muscle fibres of guinea-pig papillary muscle.
Eur J Pharmacol
; 136(2): 243-6, 1987 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-3595723
ABSTRACT
A concentration-dependent increase in force development was obtained with BM 14.478 (10(-9)-5 X 10(-4) M) in skinned fibres of guinea-pig papillary muscles. Guinea-pig papillary muscles are standard preparations for evaluating inotropic effects and they were also used in the present case for evaluating the positive inotropic effect of BM 14.478. We therefore conclude that a marked calcium-sensitizing effect contributes to the positive inotropic effect obtained with BM 14.478 even at very low concentrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
/
Benzimidazóis
/
Cardiotônicos
/
Cálcio
/
Imidazóis
/
Contração Miocárdica
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1987
Tipo de documento:
Article