Role of Keap1-Nrf2/ARE signal transduction pathway in protection of dexmedetomidine preconditioning against myocardial ischemia/reperfusion injury.

Li, Hui-Xian; Wang, Tai-Hang; Wu, Lin-Xin; Xue, Fu-Shan; Zhang, Guo-Hua; Yan, Tao

Li, Hui-Xian; Wang, Tai-Hang; Wu, Lin-Xin; Xue, Fu-Shan; Zhang, Guo-Hua; Yan, Tao.

Afiliação

Li HX; Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Wang TH; Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Wu LX; Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Xue FS; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Zhang GH; Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Yan T; Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer Hospital, Chinese Academy of Medical Sciences, Langfang 065001, China.

Biosci Rep ; 42(9)2022 09 30.

Article em En | MEDLINE | ID: mdl-35959640

Assuntos

Dexmedetomidina; Traumatismo por Reperfusão Miocárdica; Animais; Antioxidantes/farmacologia; Hidrolases de Éster Carboxílico/metabolismo; Dexmedetomidina/farmacologia; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Masculino; Traumatismo por Reperfusão Miocárdica/tratamento farmacológico; Traumatismo por Reperfusão Miocárdica/metabolismo; Traumatismo por Reperfusão Miocárdica/prevenção & controle; Fator 2 Relacionado a NF-E2/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais

Palavras-chave

Dexmedetomidine; Keap1-Nrf2/ARE signal transduction pathway; Myocardial ischemia/reperfusion injury; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Dexmedetomidina Limite: Animals Idioma: En Revista: Biosci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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